[White paper] Histamine in complex biological matrices: application to inflammation studies

Histamine is a molecule that plays a major role in local immune responses, is involved in the regulation of the physiological functions of the intestine, and acts as a neurotransmitter for the brain, spinal cord, and uterus. As part of the inflammatory response to a foreign body, histamine is produced and released by basophils and by
mast cells. An increase in local histamine levels can lead capillaries to become more permeable to leucocytes and some proteins, enabling them to attack pathogens in infected tissues.
Following its discovery in 1910, histamine has been identified as a central player in the pathophysiology of allergy and asthma, and drugs targeting its receptors have been in clinical use since the 1940s. To understand the role of histamine in inflammatory reactions as well as the immunoregulatory effects of histamine in physiology and various pathologies, it is essential to be able to measure histamine levels accurately. Bertin Bioreagent has designed the Bertin Bioreagent Histamine ELISA kit to detect and quantify histamine in complex biological matrices. The Bertin Bioreagent Histamine kit has been widely cited in inflammation studies.