Context
Neutrophils are white blood cells belonging to the granulocyte family and constitute the most abundant population of circulating immune cells in humans. They play an essential role in innate immunity, being the first cells recruited to sites of infection or tissue damage. Their main function is to phagocyte and destroy pathogens, (e.g : bacteria or fungi) through mechanisms such as the production of free radicals, the release of lysosomal enzymes, and the formation of Neutrophil Extracellular Traps (NETs).
The labeling of neutrophils is essential in biomedical research. Indeed, due to their key role in innate immunity, studying and labeling them is essential for understanding defense mechanisms, as well as their involvement in inflammatory, autoimmune, and tumor pathologies.
With a peptide-based technology, the product Myelotracker® of Bertin Bioreagent brings the labeling to another level. By specifically targeting Lactoferrin, a highly abundant protein concentrated in Neutrophil granules, Myelotracker provides a selective method for detecting Neutrophils while preventing their activation, preserving their current physiological state.
The following results demonstrate the ability of Myelotracker to label neutrophils from human samples under naive and NETs conditions.
