Challenges in Pharmaceutical Development
Improving the dissolution, solubility, and bioavailability of poorly soluble drugs (BCS Class 2) remains a significant challenge. Amorphous Solid Dispersions (ASDs) are a promising solution, stabilizing drugs in their amorphous form using polymers and low-molecular-weight excipients. However, thermodynamic instability and complex processing steps make their preparation difficult.
Limitations of Conventional Methods
Dry ball-milling has been useful in preformulation but has notable limitations. It is often inefficient, requiring large amounts of material and offering limited precision.
Innovative Solution: Precellys Evolution and Cryolys Evolution
The combination of Precellys Evolution, a high-energy 3D bead-beating system, and Cryolys Evolution with precise temperature control offers an effective alternative. This system allows rapid processing of small-volume samples, minimizing material use and improving processing efficiency.
Streamlining ASD Preparation
This approach enhances amorphization consistency, improving excipient screening for ASDs. Our application note further explores how this innovative method can optimize the preparation process and advance pharmaceutical formulation.
