Context
The blood-brain barrier (BBB) is composed of a continuous layer of endothelial cells. The BBB plays a critical role regulating the homeostasis in the central nervous system and defending it against toxins or microorganisms. The endothelium forming the BBB can be modulated by different stimulus such as inflammatory mediators.
The goal of this study was to establish an in vivo model for the assessment of the integrity of the BBB using peripheral injection of fluorescent dye sodium fluorescein (NaF) followed by the measurement of the fluorescence of NaF in the brain.
