Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages - Bertin Technologies

Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages

Karine Labadie,1,2 Thibaut Larcher,3 Christophe Joubert,1,2 Abdelkrim Mannioui,1,2 Benoit Delache,1,2Patricia Brochard,1,2 Lydie Guigand,3 Laurence Dubreil,3 Pierre Lebon,4 Bernard Verrier,5Xavier de Lamballerie,6,7 Andreas Suhrbier,8 Yan Cherel,3 Roger Le Grand,1,2 and Pierre Roques1,2

Context

The Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that induces in humans a disease characterized by fever, rash, and pain in muscles and joints. The aim of this study is to propose a new model for CHIKV infection in adult, immunocompetent cynomolgus macaques. CHIKV infection in these animals recapitulated the viral, clinical, and pathological features observed in human disease.

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