Liver Dysfunction and Phosphatidylinositol-3-Kinase Signalling in Early Sepsis: Experimental Studies in Rodent Models of Peritonitis

Peter Recknagel1,2., Falk A. Gonnert1., Martin Westermann3, Sandro Lambeck1, Amelie Lupp4, Alain Rudiger2, Alex Dyson2, Jane E. Carre´ 2, Andreas Kortgen1, Christoph Krafft5, Ju¨ rgen Popp5, Christoph Sponholz1, Valentin Fuhrmann6, Ingrid Hilger7, Ralf A. Claus1, Niels C. Riedemann1, Reinhard Wetzker8, Mervyn Singer2, Michael Trauner6", Michael Bauer1"*

Sources: 1 Integrated Research and Treatment Center, Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany, 2 Bloomsbury Institute of Intensive Care Medicine, Division of Medicine, University College London, London, United Kingdom, 3 Electron Microscopy Center, Jena University Hospital, Jena, Germany, 4 Department of Pharmacology, and Toxicology, Jena University Hospital, Jena, Germany, 5 Institute of Photonic Technology, Jena, Germany, 6 Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria, 7 Institute of Diagnostic and Interventional Radiology, Jena University Hospital, Jena, Germany, 8 Department of Molecular Cell Biology, Center for Molecular Biomedicine, Jena University Hospital, Jena, Germany

PLoS Med 9(11): e1001338. doi:10.1371/journal.pmed.1001338, Academic Editor: Jean-Louis Vincent, Free University of Brussels, Belgium, Received January 16, 2012; Accepted October 2, 2012; Published November 13, 2012