Poor water solubility remains one of the major challenges in pharmaceutical development. During the preformulation stage, researchers must rapidly identify the most suitable approaches to improve the dissolution of their drug candidates while working with limited quantities of active pharmaceutical ingredients (APIs). Between tight timelines, scarce compounds, and the need to make informed decisions early in development, every milligram of API counts.
To address these challenges, Precellys & Cryolys enable the exploration of multiple formulation strategies at small scale while minimizing sample heating and material consumption. Combining high-performance 3D Bead Beating technology with temperature control, these solutions provide a flexible approach for rapidly evaluating formulation parameters, excipients, and processing conditions while preserving sample integrity.
In our new White Paper, discover four practical application notes covering amorphization, nanomilling, micro- and nanosuspensions, as well as micromilling of poorly water-soluble APIs. Learn how to identify the most promising formulation strategies, optimize your preformulation studies, and maximize results while minimizing API consumption.
